Dermatologist Designed Skin Care Made Simple


Serum 6

Your six-in-one, essential serum.

Offering intense hydration, smoothing, brightening, and protection from pollution and environmental factors, Serum 6 contains all you need to optimize the health and appearance of your skin, delivering glowing, youthful results.

The more you use it, the better it works.

Contains 15+ medical-grade vitamins, antioxidants, peptides, amino acids, probiotics and plant stem cell extracts in an opulent, silky texture for maximum performance.

The 6 Superstar Actives

Antioxidants counteract the harmful effects of environmental pollution, free radicals and UV radiation for optimal long-term skin health.

The science behind it:

Our plant-based antioxidant blend is formulated with Vitamin C, Niacinamide, Alpine Edelweiss Flower, French Maritime Pine Tree, Malus Domestica Fruit Cell Culture Extract, Shiitake Mushroom Extract, and Avena Sativa. Vitamin C boosts collagen production, protects from free radicals and environmental toxins, and brightens skin. Alpine Edelweiss Flower suppresses skin wrinkling and inflammation. French Maritime Pine Tree recycles oxidized Vitamin C so it can be used again while also increasing skin elasticity and hydration.

Peptides boost production of six major components of the skin matrix, resulting in a more even skin tone and helping to reduce the appearance of wrinkles.

The science behind it:

Palmitoyl Tripeptide-38, also known as Matrixyl synthe’6, boosts production of six major components of the skin matrix: Collagen I, III, and IV, fibronectin, hyaluronic acid and laminin 5, resulting in more even skin and fewer wrinkles, especially on the forehead and around the eyes.

Multi-molecular Weight Hyaluronic Acid hydrates, smooths and plumps by penetrating various skin layers.

The science behind it:

Multi-molecular weight hyaluronic acid penetrates to varying levels of the skin, performing different functions at each: hydrating deep while smoothing and plumping closer to the surface. Sodium hyaluronate is a low molecular weight hyaluronic acid that has the ability to penetrate into deep layers of the skin, attracting and binding up to 1000 times its weight in water to hydrate, plump and reduce the appearance of wrinkles.Hydrolyzed hyaluronic acid is higher weight, working on the skin’s surface to attract and bind up to 1000 times its own weight in water to help hydrate the skin at its surface.

Plant-derived Stem Cells enhance the vitality of skin cells, increase skin density and reduce the appearance of wrinkles.

The science behind it:

Malus Domestica Fruit Cell Culture Extract is derived from a rare Swiss apple variety, and is shown to help skin cells maintain capacity to build new tissues, increase skin density, increase vitality of epidermal stem cells, and reduce the appearance of wrinkles. Pseudoaltermonas Ferment Extract is found in deep seawater. This soothing and anti-inflammatory botanical helps skin retain moisture and promotes skin regeneration by stimulating production of collagen and elastin.

Probiotics increase skin’s defense mechanisms and reduce redness. 

The science behind it:

Lactobacillus Ferment Lysate Filtrate, a soothing probiotic, has been shown to increase skin’s defense mechanisms and decrease irritation and redness. In vitro, it has also proven to promote oxygen uptake, collagen production and synthesis of ATP (the energy molecule our body produces and uses).

Niacinamide brightens skin tone and minimizes the appearance of pores.

The science behind it:

When applied to the skin, this powerful antioxidant helps to minimize enlarged pores, brighten skin tone, minimize dullness, and strengthen the skin barrier. Niacinamide functions as an anti-inflammatory and helps skin to retain moisture.


Serum 6 should be applied to clean skin twice daily after cleansing. Top it off with your favorite sunscreen during the day, or may be used with a retinoid at night.

For all skin types.

Customer Reviews

Based on 38 reviews
Simply the BEST!!

Serum 6 is my very favorite skin care product and the only one I need morning and night (besides sunscreen). It is gentle, yet effective. The serum is moisturizing and allows makeup to go on over it flawlessly. It is simply the best!!

Just starting 2nd bottle

I am 66 and not sure how long it takes to notice an improvement. So far I can see no change in my skin, but this may work very well for younger skin. Hoping it just takes awhile & giving a second bottle a try.

Stephanie Ernst
Love this product!

I’ve been so happy with Serum 6. My skin is more clear and soft since using it. I don’t need to use any separate moisturizer. It goes on completely clear and leaves no residue, and doesn’t interfere with my makeup. It really couldn’t be easier!

One and done

I love the idea that instead of using 3 products, I can use one. Hopefully, the benefits are there. With serum, it's hard to know what it does, but if it is working, and I assume it is, it is easy and fast to use, and I'm all for that.

Laura Dowaliby
It’s Nice Stuff

I heard Dr. Marcus talk about this product on the radio. I decided to try it. It’s very nice. My skin likes it. My face feels good. I have only been using it for a month. But I think it’s working on my wrinkles.